Baclofen And Tramadol: Uses, Side effects, Interactions, And More

Baclofen and Tramadol

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Baclofen is a generic medicine used to treat muscle spasms caused by certain conditions such as spasticity associated with spinal cord injury and diseases such as Multiple Sclerosis. Baclofen, also known as Kemstro and Lioresal under the brands Kemstro and Lioresal, is a prescription medicine used to treat multiple sclerosis and spinal cord injuries to relieve muscle spasms. Interactions and reaction effects can also occur when taken with over the counter pain medications.

Tramadol has been shown to influence several other pain modulators of the central nervous system, non-neural inflammatory markers, and immune mediators. Apart from its SNRI activity, Tramadol also has anxiolytic, antidepressant, and chills effects and has been shown to have comorbidities with pain. Serious interactions with Tramadol have occurred with other opioids such as oxycodone and fentanyl.

According to the US National Library of Medicine, the drug relieves spasms in the muscular system, relieves pain, and improves muscle movement. Baclofen has been increasingly used in the treatment of drug and alcohol addiction over the past decade. Prescribing a drug to treat addiction is considered off-label use. Still, the FDA has approved its use because treatment has shown results in clinical trials, according to a study published in the Cochrane Database of Systematic Reviews.

Metaxalone is a generic alternative to branded drugs such as Skelaxin but can be expensive. Insurers don’t like to cover this, so there are cheaper alternatives. Metaxalone, which takes 800 mg tablets 3-4 times a day, is similar to Skelaxin but has fewer reported side effects, has lower sedation potential, and is a muscle relaxant based on clinical trials.

What are the reasons one would think of taking Baclofen and Tramadol together?

Baclofen is used to treat pain and a certain type of muscle stiffness and tightness, multiple sclerosis, spinal cord injuries, or other spinal cord diseases.

On the other hand, Tramadol is used to cure pain. It is used to treat long-lasting pain when other drugs failed.
Extended-release tramadol products are designed to help people with chronic pain. Their 24 / 7 effectiveness prevents pain from recurring later in the day and promotes better sleep.

What are the Side Effects of Baclofen?

Some serious side effects of this medication which needs emergency medical help are-

  • Seizures
  • Seeing anything or hearing to sounds that do not exist

Other side effects are-

  • Dizziness
  • Weakness
  • Confusion
  • Headache
  • Nausea
  • Constipation
  • Difficulty falling asleep or staying asleep
  • Tiredness
  • Frequent urination

Tell your doctor if the symptoms turn serious and do not go away.

The problem with Baclofen and addiction is that addiction is a problem that affects people of all populations. Studies to date have shown no geriatric problems, which limits the usefulness of tablets for older people.

Baclofen Drug Interactions

There is a total sum of 347 drugs that interact with Baclofen.
25 major, 321 moderate, and 1 minor drug interaction.

Some of them are-
• Ambien
• Benadryl
• Cymbalta
• Fish Oil
• Klonopin
• Lyrica
• MiraLAX
• Neurontin
• Norco
• Singulair

What is Tramadol used for?

Tramadol 50mg is use to treat gentle to slightly severe pain. It is an opioid painkiller. Tramadol was launched in 1977 in Germany and is used to treat acute and chronic pain in the form of tablets, dissolved powder, syrup, and liquid compresses.

The advanced release form of Tramadol is available in capsules that contain more medications than the instant release tablets. Instead of being taken every day, the extended-release version is formulated to be released into the body over a 24-hour period. The maximum dose of drug release is 300 mg per day.

What are the Side Effects of Tramadol?

Some common side effects are-

  • Nausea
  • Vomiting
  • Constipation
  • Lightheadedness
  • Dizziness
  • Drowsiness
  • Headache

Seek immediate medical help if you have serious side effects, including- mental or mood changes, severe stomach pain, Difficulty urinating, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss), fast/irregular heartbeat, severe dizziness, fainting and seizure, rash, itching/swelling (especially of the face/tongue or throat), severe dizziness, trouble breathing.

If any side effects worsen or stay longer in your body, please get in touch with your physician to avoid further problems.
In patients taking both Tramadol and Baclofen, the drug can worsen the effects of both and cause unwanted side effects. This can lead to death in people with seizures, making it difficult to treat back pain, depression, or alcohol withdrawal syndrome.

Tramadol Drug Interactions.

There is a total sum of 542 drugs that interact with Tramadol.
293 major, 246 moderate, and 3 minor drug interactions.

Some of the names are-

  • Ambien
  • Aspirin Low Strength
  • Benadryl
  • Celebrex
  • Cymbalta
  • Flexeril
  • Lipitor
  • Lyrica
  • Nexium
  • Norco
  • Singulair
  • Synthroid
  • Tylenol

Is it safe to take Baclofen and Tramadol together?

Yes, it is safe to take both medicines together. But it also depends on some factors like your age, weight, health conditions, tolerance, etc.
Consider the side effects and other precautions before taking both drugs.

Precautions when taking Baclofen and Tramadol together.

Utilizing narcotic ache or cough remedies together with other medications that also affect central nervous system depression can lead to severe side effects, including respiratory discomfort, coma, and even death.

  • Your doctor may also prescribe a different medication that does not interact or may also adjust with the dosages.
  • Take care that you do not consume alcohol or take the medications independently without a doctor’s prescription.
  • Avoid working on any hazardous machinery while on these medications until you know how they affect you.
  • Brief your doctor about the medications you consume.
  • Never stop using the medications on your own. First, talk to your doctor.


Ripple MG, Pestaner JP, Levine BS, Smialek JE. Lethal combination of tramadol and multiple drugs affecting serotonin. Am J Forensic Med Pathol. 2000 Dec;21(4):370-4. doi: 10.1097/00000433-200012000-00015. PMID: 11111800.  Accessed on 28/07/2021