Is it Safe to take Tramadol and Naproxen Together?

tramadol and naproxen together

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Tramadol belongs to the Narcotic analgesics drug class. The medicine is prescribed to manage average to severe pain. The drug is similar to an opioid.

Naproxen belongs to the Nonsteroidal anti-inflammatory drugs class. The medication is used to cure pain and inflammation caused by circumstances such as arthritis, ankylosing spondylitis, tendinitis, bursitis, or menstrual cramps. It can be also used in curing acute pain.

Are Aleve and Tramadol the same thing?

Tramadol works in relieving pain, fever, and inflammation in the body. On the other hand, Aleve works well for treating mild to moderate pain or inflammation and lasts longer than other NSAIDs.
Tramadol acts in the central nervous system to calm the pain. Whereas, Aleve works by decreasing hormones that induce inflammation and pain in the body.

What are the Main Differences between Naproxen and Tramadol?

In Naproxen, there is a total of 389 drug interactions. Some of the drug names are- Aspirin Low Strength (aspirin), Benadryl, Cymbalta, Fish Oil (omega-3 polyunsaturated fatty acids), Flexeril, Flonase, Lexapro, Lyrica, and many others.
Whereas in tramadol there is a total of 542 frug interactions. Some of the drug names are- Xanax, Zoloft, Zyrtec (cetirizine), and many others.

Naproxen dosage comes in the form of oral suspension, oral tablet, oral delayed-release tablet, oral tablet, extended-release, oral capsule, compounding powder, oral and topical kit.
On the other hand, Tramadol dosages come in the form of oral tablets, oral tablets, extended-release, oral capsule, extended-release, oral tablet, disintegrating, oral liquid.

The use of naproxen in pregnancy is not advised due to certain complications, it should be only used when it is prescribed by your physician, tramadol comes in category C and is also not used during pregnancy due to insufficient data in humans.

Common side effects of naproxen are bruising, itching skin, swelling, etc. And for tramadol, side effects include pruritus, agitation, stress, constipation, diarrhea, hallucination, tremor, vomiting, etc.

Consult your doctor before giving Naproxen to kids under 12-year-old. On the other hand, tramadol should not be given to people younger than 18 years old.

Can you take Naproxen and Tramadol together?

Tramadol and Naproxen are a combination used to treat acute pain that is strong enough to require an opioid painkiller. Tramadol 50 mg is used to relieve moderate to severe pain including pain after surgery.

Naproxen can increase blood levels and the risk of side effects if taken with another medication. There is an increased risk of intestinal bleeding if you take naproxen along with other medications that increase the risk of bleeding as such. This is a misnomer, as Tramadol and Naproxen can be taken together with additional vitamins and there is a higher risk of reactions when trying to get the disease and its performance factors.

  • Tramadol is often prescribed to people when no other medications are working well or not tolerated.
  • Doctors prescribed both the drugs together as they can offer better relief than only one drug.
  • Sometimes, your physician will recommend the smallest dose to offer the best suitable relief to patients instead of giving a high dose of only one drug.
  • Some side effects may increase in which might be more common in adults.
  • It is safe to take the mixture of both the drugs for people above 18-years-old.
  • Always talk and consult your doctor before taking any medications or changing any drugs.

What are the side effects of Tramadol and Aleve?

The side effects of tramadol are usually mild and decrease after a while. However, the use of tramadol and NSAIDs can exacerbate side effects that are more common in older adults and people with chronic illnesses.
Common Side effects include- constipation, nausea, vomiting, stomach pain, dizziness, sleepiness, tiredness; headache; or itching.
Seek medical assistance if you have- agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, loss of coordination, nausea, vomiting, or diarrhea.

Visit your doctor once if you experience side effects such as:

  • noisy breathing, sighing, shallow breathing,
  • breathing that stops while sleep
  • a slow heart rate
  • a light-headed sense
  • low cortisol

Common side effects include- indigestion, heartburn, abdomen pain, nausea; headache, dizziness, drowsiness, itching, rash; or ringing in your ears.

Seek medical assistance if you have signs of heart attack or stroke or allergic reaction like- wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Stop using the medications if you have-

  • shortness of breath
  • swelling or rapid weight gain
  • the first sign of any skin rash
  • signs of stomach bleeding
  • liver problems
  • kidney problems
  • low red blood cells – pale skin, sensing light-headed or short of breath, fast heart rate, difficulty concentrating.
  • severe skin reaction.

The medication can slow your breathing and also there are changes that death may occur. Ask someone to monitor you and seek prompt medical help if you are experiencing slow breath with long pauses, or are hard to wake up.
If any of the side effects worsen or don’t go away, it is recommended to take medical help.

Which Drug Interacts with Naproxen and Tramadol?

Naproxen –
Total drug interaction- 389
Moderate- 281
Minor- 18

Some drugs are-

  • Lyrica (pregabalin)
  • Nexium (esomeprazole)
  • Norco (acetaminophen / hydrocodone)
  • ProAir HFA (albuterol)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)

Tramadol –
Total drug interaction- 542
Major- 293
Moderate- 246
Minor- 3

Some of the drugs are-

  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Aspirin

Are Aleve and Tramadol Addictive?

Researchers have observed that Misuse of tramadol and Aleve can lead to addiction. To avoid the dependency here are some suggestions-

  • Follow your doctor’s suggestion while dosing
  • Do not over or underdose.
  • While dosing, consume as much as your doctor has prescribed for you.
  • In case of any queries or adverse side effects always talk to your doctor.


Though the uses of both are drugs differ from each other, according to health care experts’ tramadol and naproxen can be taken together as this combination can lead to effective relief in pain. They believe that giving only one drug cannot be as effective as compare to the combination of drugs. High care should be taken of people who are allergic to any of the drugs. Always brief your doctor about your medical history. Taking proper precautions and dosing as per the doctor’s recommendation will make your side safer.

Always learn about the side effects, warnings, and precautions of tramadol before combining any drug combination. Discuss with your doctor if the combination will suit you or not.
Check with experts if you have any queries or doubts.


Tramadol 50mg is significant superior analgesic over naproxen.

Tramadol is used to treat moderate and severe pain. It helps in calming the pain.

Drowsiness is one of the side effects of naproxen. People consuming the drug should avoid driving, activity on any hazardous machines, or anything that required mental alertness.

Taking 2 naproxen of 500 g will not kill you but it is not recommended for regular use. Also, the maximum hour dose is every 12 hours of 500 mg. The side effects may increase because of the high dose. Visit your doctor once for more detailed information.


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Nevriana, A., Möller, J., Laflamme, L. et al. New, Occasional, and Frequent Use of Zolpidem or Zopiclone (Alone and in Combination) and the Risk of Injurious Road Traffic Crashes in Older Adult Drivers: A Population-Based Case–Control and Case-Crossover Study. CNS Drugs 31, 711–722 (2017). Accessed on 12/08/2021