Tramadol Uses Warnings and Precautions

tramadol uses warnings and precautions

Tramadol Uses Warnings and Precautions.

Tramadol is an orally administered pain relief medication that helps to alleviate moderate and moderately severe forms of ongoing pain. It works in the brain by changing how your body responds to painful stimuli, similar to opioid analgesics.
Tramadol is available under different brand names: Ultram, Ultram ER (extended-release), Ryzolt, and ConZip. The risk of addiction to most opioid medications is usually high. However, the risk of addiction to Tramadol isn’t very high.
This medication must be prescribed by a doctor and is only available with a prescription. It’s essential to take Tramadol exactly as your doctor prescribes; always ensure that you’re taking it accordingly!

Uses of Tramadol

Tramadol is a synthetic opioid that mimics the sensation of pain to block it. It is a narcotic-like pain relieving oral medicine that treats moderate to severe pain in adults.
The immediate-release generic tramadol tablets are used in acute pain situations. In contrast, extended-release capsules and tablets are usually reserved to treat chronic pain and when treatment is needed around the clock.
Tramadol is used to treat pain such as neuropathic pain or osteoarthritis pain & the medication may also be prescribed for lower back pain or rheumatoid arthritis. Enova RX-Tramadol is used to treat musculoskeletal pain, such as backaches.
The drug may be used as part of combination therapy. Taking it with other medications is common to treat severe chronic pain and is a critical treatment process.


Addiction and Misuse Warning: To protect yourself from Tramadol addiction and misuse, take this drug exactly as prescribed by your doctor. If you have any concerns about the warning or need further information, speak with your health care professional immediately!

Slowed or Stopped Breathing Warning: Tramadol can slow or stop your breathing; if it isn’t treated immediately, it may even lead to death. This risk is highest within three days of starting the drug or increasing your dosage.

Accidental Ingestion Warning: If anyone, especially children, accidentally takes this drug, consult the healthcare physician immediately as it could be fatal. To protect the young ones, keep these pills out of reach.

Life-Threatening Effects for Children Warning: Tramadol should not be used in kids younger than 18 who have certain risk factors or after having a tonsillectomy or adenoidectomy. Also, it shouldn’t be given to children under 12 because their bodies might process the medication too quickly and lead to slowed breathing or even death.

Neonatal Opioid Withdrawal Syndrome Warning: Taking this medication for a long time while pregnant can cause withdrawal in your baby, and withdrawal in babies can be fatal. Some of the symptoms are irritability, hyperactivity, and an unusually high-pitched cry. They may also include tremors, vomiting, diarrhea & failure to gain weight.

Interactions with certain Drugs Warning: Taking Tramadol with certain drugs can cause varied serious effects. These effects include increased levels of the drug, which may lead to seizures and serotonin syndrome. The drugs that can cause these effects to include Amiodarone, Quinidine, Erythromycin, Ketoconazole, Ritonavir. 

Interactions with Benzodiazepines Warning: While on benzodiazepines and other similar drugs, taking Tramadol can cause severe health effects. These include severe fatigue, slowed breathing, coma, and death.

Tramadol is Associated with many other Warnings-

Seizures Warning: Tramadol can cause or worsen seizures, so it’s essential to take the proper precautions. The risk of seizures is higher if you take certain other medications, including opioids and antidepressants; naloxone may be used in case of overdose, which also increases the chances of a seizure.

Allergy Warning: Tramadol can cause severe allergic reactions, including:

  • Difficulty breathing
  • Swelling of your face, lips, throat, or tongue
  • Severe itching
  • Hives (itchy welts)
  • Blistering or peeling skin

Alcohol interaction: Drinking with Tramadol can cause dangerous side effects such as slowed breathing, decreased heart rate, and blood pressure or confusion. You should avoid drinking while taking Tramadol to avoid these risks. 

Warnings for People with Certain Health Conditions:

For people with Seizures: If you have a history of seizures or any potential for having them, Tramadol can worsen your condition. Be sure to consult with a doctor before taking it and discuss whether it is safe or not.

For people with Mental Health Problems: If you have thoughts about intentionally hurting yourself, or if you’ve hurt yourself already, then avoid taking Tramadol.

For People with Addiction Problems: If you have a history of addiction, do not take Tramadol. Also, avoid this drug if you are experiencing problems with addiction, such as alcohol or drugs addictions.

For People with Head Injuries: Tramadol can increase the pressure inside your head, which could worsen your condition or make it difficult for doctors to diagnose and find the cause of the problems. Consult with your healthcare physician whether Tramadol is safe for you. 

For people with Stomach Problems: Tramadol is safe for some people but can make certain stomach problems worse. It may also interfere with doctors’ ability to diagnose or find the cause of problems. Make sure you talk things over with your doctor before starting it.

For People with Kidney Problems:

  • Tramadol Immediate-Release Tablet: If you have kidney problems or a history of kidney disease, your body may not clear this drug from it well. This can increase the levels of Tramadol in your body and cause more side effects.
  • Tramadol extended-release tablet: If you have severe kidney problems, it is not advised to use the extended-release form of Tramadol.

For people with Breathing Problems: Tramadol may slow your breathing and cause shallow breathing. If you already have a respiratory condition, such as asthma, talk with your healthcare physician about whether this drug is safe for you.


Warnings for Other Groups

For Senior Citizens: Due to the decreased functionality of kidneys and livers, older adults’ bodies may be unable to process drugs as quickly. As a result, the drug stays in their system for more extended periods resulting in an increased risk of side effects from an extended-release form of Tramadol.

For children:

  • Tramadol Immediate-Release Tablet: The drug is not safe and effective for children, it should not be used in children younger than 17 years old.
  • Tramadol Extended-Release Tablet: The safety and effectiveness of this drug for children are unknown. It is not recommended to use in people younger than 18 years old.


Tramadol has adverse and life-threatening side effects, including respiratory depression. Hence your healthcare physician must examine your medical & mental health history before prescribing it to you. You should let your doctor know if you have any respiratory conditions or a personal history of alcoholism and drug addiction.

Avoid the use of Tramadol if any of the following conditions apply:

Allergy or Hypersensitivity: Avoid taking Tramadol if you have an allergy or hypersensitivity to opioids like Tramadol.

Risk factors for Respiratory Depression (adolescents): Those who have a respiratory impairment and recovering from surgery should not take Tramadol. This includes those with obstructive sleep apnea, obesity, severe pulmonary disease or neuromuscular disease, or taking other medications that can cause respiratory depressive effects.

Tonsillectomy or Adenoidectomy before age 18: Tramadol should not be used to manage pain after surgical removal of the tonsils and adenoids in those younger than 18 years old.

Pre-existing Respiratory Depression: If you have pre-existing respiratory depression, using Tramadol can increase the risk of severe breathing issues and even death.

Gastrointestinal Obstruction: If you have a known or suspected gastrointestinal obstruction, do not take Tramadol. Tramadol can cause paralytic ileus and should be immediately discontinued in these patients.

Seizures: If you have a history of seizures or epilepsy, talk to your doctor before taking this drug. Your risk for seizure increases if you take it with other medications linked to convulsions and head injuries.